观察视网膜和动脉中的自然曲脉冲波,以估计壁面弹性
Gabrielle Laloy-Borgna1, Léo Puyo2, Hidero Nishino3
1LabTAU, INSERM, Centre Léon Bérard, Université Lyon 1, Univ Lyon, F-69003, Lyon, France.
Science advances
|June 21, 2023
概括
研究人员在动脉和静脉中发现了一种新型的脉冲波,即曲脉冲波. 这种使用光学和超声波方法测量的新型波可能作为血管衰老的生物标志物.
科学领域:
- 生物医学工程 生物医学工程
- 心血管生理学心血管生理学
- 医疗成像医学成像
背景情况:
- 动脉弹性对心血管健康至关重要,通常使用脉冲波速度进行评估.
- 现有的方法,如超声波和光学测量视网膜动脉脉冲波速度,在准确性和一致性上有局限性.
- 莫恩斯-科尔特韦格方程描述了对称波速和动脉壁弹性之间的关系.
研究的目的:
- 报告了对一个反对称的脉冲波的第一个观察和描述,称之为曲脉冲波.
- 为了研究这种曲脉冲波作为血管衰老的新生物标志物的潜力.
主要方法:
- 在视网膜动脉和静脉中体内测量波速,使用专门的光学系统.
- 使用引导波理论,理论上证实了曲脉冲波的存在和低速度.
- 使用超快超声波成像检测动脉中的自然曲波.
主要成果:
- 在血管系统中,首次观察了曲脉冲波,一种反对称的波形态.
- 在视网膜血管中曲脉冲波的体内速度估计在1到10毫米/秒之间.
- 通过理论分析和试验检测在动脉中证实这种低速波形态的存在.
结论:
- 曲脉冲波代表了第二个自然脉冲波,与先前已知的对称波不同.
- 这种新发现的波形模式具有作为评估血管衰老的非侵入性生物标志物的巨大潜力.
- 光学和超快超声波成像技术的进步正在为血管生物力学提供新的见解.
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