前丘脑和皮质之间的功能网络动态在的深度大脑刺激中
Giovanna Aiello1,2,3, Debora Ledergerber2,3, Tena Dubcek1,2,3
1Decision Neuroscience Lab, Department of Health Sciences and Technology, ETH Zurich, 8092 Zurich, Switzerland.
thalamus (ANT) 前核的深度大脑刺激 (DBS) 显示出对抗药性的承诺. 较高的太太振荡和ANT-到头皮连接性预测患者的成功治疗结果.
科学领域:
- 神经科学是一个神经科学.
- 发病学 (Epileptology) 是一个专业的学科.
- 生物医学工程 生物医学工程
背景情况:
- thalamus的前核 (ANT) 是潜在的深度大脑刺激 (DBS) 对抗药性的潜在目标,因为它与皮层区域的连接性以及在传播中的作用.
- 人们对中ANT DBS的精确时空动态和功能机制的理解仍然不充分.
研究的目的:
- 为了研究人类的ANT和新皮层之间的体内相互作用动态.
- 描述有效治疗的神经功能机制的 ANT DBS.
- 为了确定预测对ANT DBS治疗反应的手术内神经生物标志物.
主要方法:
- 在15名耐药性患者接受双边ANT DBS时,从ANT和头皮EEG同时进行手术内电生理学记录.
- 分析ANTT振荡活动,ANTT与头皮的功能连接,以及在手术内刺激期间的EEG变化.
- 电生理学发现与植入后6个月发作频率减少的相关性.
主要成果:
- 安特表现出高振幅的西塔 (4-8赫兹) 振荡,特别是在它的上部.
- 最强的ANT-to-scalp功能连接是在ipsilateral中心前部区域的theta带中观察到的.
- ANT DBS刺激降低了较高的EEG频率 (20-70 Hz) 并增加了头皮与头皮之间的连接.
- 响应ANT DBS的患者表现出更高的基线EEG θ振荡,更大的ANT θ功率,以及增强的ANT-到头皮 θ连接.
结论:
- 在症中,THA振荡在ANT和皮质之间的网络动态中发挥着关键作用.
- 识别治疗前的活动和连接性可以帮助预测和优化抗药性的ANT DBS反应.
- 这项研究提供了关于ANT-皮层相互作用的关键见解,有助于改进的DBS治疗.
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