人的身高:一个模型常见复杂的特征特征
Mitchell Conery1,2,3, Struan F A Grant1,2,4,5,6
1Division of Human Genetics, Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Annals of human biology
|June 21, 2023
概括
人类身高遗传学虽然高度遗传且易于测量,但在全基因组关联研究 (GWAS) 中可能达到了极限. 这表明未来的研究应该专注于多基因分数和复杂特征的变异对基因映射.
科学领域:
- 人类遗传学 人类遗传学
- 复杂的表型复杂的表型
- 定量性质特征遗传学 遗传学
背景情况:
- 人的身高是一个复杂的表型,受遗传和环境因素的影响.
- 它的测量方便使得高度成为其他复杂特征的常见代理,尽管可概括性需要仔细考虑.
- 了解身高遗传学可以了解更广泛的复杂特征遗传模式.
研究的目的:
- 评估身高作为其他复杂现象型的模型.
- 审查身高遗传学的进展及其对复杂特征的影响.
- 评估当前遗传研究方法对复杂特征的适用性.
主要方法:
- 在PubMed和谷歌学者的综合文献搜索.
- 专注于有关身高遗传学及其与其他表型相比的文章.
- 对最近的全基因组关联研究 (GWAS) 结果的分析.
主要成果:
- 身高具有很高的遗传性,并且很容易测量,类似于许多复杂的表型.
- 通过GWAS已经确定了超过12,000个独立的身高遗传信号.
- 常见的单核酸多态变异,对身高的遗传性,在欧洲祖先种群中接近和.
结论:
- 关于身高的GWAS和表明了全源模型的潜在局限性.
- 未来的研究可能会越来越多地依赖复杂特征的多基因分数和风险分数.
- 越来越需要大规模的变异对基因映射计划.
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