激活Mu-Delta阿片类受体异构体 阻止吗啡奖励效应
Ariadna Requana Aradas1, Youssra Djaboub1, Isabelle McCort-Tranchepain2
1Université Paris Cité, CNRS, Inserm, Pharmacologie et thérapies des addictions, Paris, France.
The international journal of neuropsychopharmacology
|June 21, 2023
概括
使用CYM51010准mu类阿片类受体 (MOR) /delta类阿片类受体 (DOR) 异构体显示出阻断吗啡奖励的前景. 这种新的方法可以减少阿片类药物的副作用,同时保持治疗效益.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
- 药物成研究 药物成研究
背景情况:
- 片受体异构体,特别是片受体 (MOR) /片受体 (DOR) 异构体越来越多地被识别出来.
- 针对这些异构体提供了一个潜在的策略,以减轻阿片类药物的副作用,如耐受性和依赖性.
- CYM51010,一种MOR/DOR异构体偏好激动剂,表现出类似于吗啡的抗受,耐受性降低.
研究的目的:
- 为了研究CYM51010对小鼠中与药物成有关的行为的影响.
- 评估CYM51010在阻断吗啡诱导的奖励和依赖方面的潜力.
主要方法:
- 评估CYM51010对小鼠运动运动活动,心理运动敏感性和条件化的位置偏好的影响.
- 评估CYM51010对吗啡诱导的身体依赖和恢复条件化的位置偏好的影响.
主要成果:
- CYM51010诱导了急性运动运动活动,精神运动敏感化和奖励效应,类似于吗啡.
- 与吗啡相比,CYM51010产生了较少的身体依赖.
- CYM51010阻止了灭的吗啡诱导的条件位置偏好的恢复,但不是吗啡诱导的身体依赖.
结论:
- 用CYM51010这样的药物准MOR-DOR异构体是阻止吗啡奖励的有希望的策略.
- 这种方法可能为管理阿片类药物成和相关副作用提供了一种新的治疗途径.
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