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雄激素代谢的替代途径和敏感性窗口的替代途径
Marilyn B Renfree1, Geoff Shaw1
1School of BioSciences, The University of Melbourne, Melbourne, Victoria, Australia.
The Journal of endocrinology
|June 21, 2023
概括
一个新发现的替代途径从adiol形成二二 (DHT),这对各种物种的男性发育和雄性化至关重要. 这一发现影响了对诸如先天性上腺增生和PCOS等疾病的理解.
科学领域:
- 内分泌学 在内分泌学.
- 发展生物学 发展生物学
- 生殖科学 生殖科学
背景情况:
- 二 (DHT) 是雄激素作用的关键媒介.
- DHT形成的经典途径涉及丸激素5α降低的目标组织.
- 通过醇氧化存在DHT合成的替代途径.
研究的目的:
- 讨论在塔玛·瓦拉比的丸中发现替代性醇途径.
- 阐明这种途径在男性男性化中的作用及其在哺乳动物中的存在.
- 探索这种途径在人类异常病毒化条件中的含义.
主要方法:
- 讨论了Tammar wallabies中adiol通路的偶然发现.
- 审查了关于这种途径在哺乳动物丸中的存在和功能的证据.
- 分析了替代途径在CAH,46,XY DSD和PCOS等疾病中的作用.
主要成果:
- 另一个途径在丸中形成阿醇,它被分泌并转化为DHT.
- 这一途径对于Tammar wallabies的泌尿器官系统病毒化至关重要.
- 该途径在青春期的哺乳动物丸中被保留,并且与男性的类固醇5α-减少酶1功能有关.
- 这种途径的异常活动有助于CAH,46,XY DSD和PCOS的女性新生儿的病毒化.
结论:
- marsupials,动物和人类的正常男性发育需要经典和替代 (后门) DHT合成途径.
- 替代途径为性发育障碍和PCOS的病理生理学提供了新的理解.
- 这一发现突显了类固醇5α-减少酶1在男性发育中的关键功能.
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