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普罗哈普特球蛋白是结直肠癌的可能预后生物标志物

Koichi Morishita¹, Jumpei Kondo¹, Daisuke Sakon¹

¹Department of Molecular Biochemistry and Clinical Investigation Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Biochemical and biophysical research communications

|June 21, 2023

概括

普罗哈普特球蛋白 (proHp) 显示出作为结直肠癌 (CRC) 的预后生物标志物的潜力. 血清proHp水平升高与晚期CRC阶段和较差的存活率相关,proHp影响癌细胞行为.

科学领域:

在瘤学瘤学.
生物化学生物化学
癌症生物标志物癌症生物标志物

背景情况:

基化合球蛋白是已知的癌症生物标志物,但其前体合球蛋白 (proHp) 在结直肠癌 (CRC) 中的作用尚不清楚.
研究proHp作为潜在的CRC生物标志物,了解其生物功能对于推进癌症诊断和治疗至关重要.

研究的目的:

为了确定前列腺血球蛋白 (proHp) 是否可以作为结直肠癌 (CRC) 的预后生物标志物.
阐明proHp在CRC进展中的生物功能.

主要方法:

在74名CRC患者的血清proHp水平被量化,使用西式涂抹.
用10-7G单克隆抗体对17个CRC组织段进行免疫组织化学检查.
通过在CRC细胞系中过度表达它来评估亲肝球蛋白的生物功能.

主要成果:

血清proHp水平与晚期临床阶段和CRC患者的预后较差相关.
大约50%的原发性CRC组织中的免疫细胞显示为10-7G的阳性染色.
在CRC细胞中过度表达proHp诱导了类似上皮层-介质细胞过渡的变化和增强的细胞迁移.

结论:

普罗哈普托格洛宾 (proHp) 显示出作为结直肠癌 (CRC) 的预后生物标志物的潜力.
这项研究提供了proHp与CRC进展相关的特定生物活动的第一个证据.

关键词:

结肠直肠癌是一种癌症.在EMT中,EMT是EMT.移民移民移民亲 - 哈普托格洛宾是什么?

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