预测光神经炎第一次发作后的最终临床表型
Shlok Sarin1, Nikhil Modak2, Rongyi Sun1
1Case Westerns Reserve University School of Medicine, Cleveland, OH, United States of America.
Journal of neuroimmunology
|June 21, 2023
概括
预测视神经炎 (ON) 的临床结果可以在早期进行. 诸如种族,MRI发现和年龄等因素有助于确定它是否存在.
科学领域:
- 神经免疫学 神经免疫学
- 眼科医生 眼科 眼科
- 神经学 神经学
背景情况:
- 视神经炎 (ON) 可以是一个孤立的事件,也可以是慢性神经免疫疾病的信号.
- 确定最终临床表型的早期预测因素对于患者管理至关重要.
研究的目的:
- 评估预测最终临床表型的因素,在初始孤立攻击光神经炎 (ON) 后.
主要方法:
- 追溯分析了64名患者的初始单独的ON.
- 在最终的表型中比较了人口统计学,临床和成像预测因素:多发性硬化症 (MS),异常性ON,神经omyelitis optica光谱障碍 (NMOSD),髓寡干细胞糖蛋白相关疾病 (MOGAD) 和二次ON.
主要成果:
- 最终的表型包括MS (34%),异常ON (22%),MOGAD (17%),NMOSD (16%) 和二次ON (11%).
- 预测因表型而异:例如,白人种族和脑MRI脱髓化为MS;年龄较大和PLEX要求为NMOSD;非洲裔美国人种族和光学MRI发现为MOGAD.
结论:
- 在最初呈现时,ON的最终临床表型可能是可以预测的.
- 人口统计,治疗反应,脑后镜,OCT和MRI是关键预测因素.
- 早期预测可以指导ON患者的预后和管理决策.
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