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纳夫托基作为STAT3抑制剂的合成和结构-活性关系研究

Mitsuaki Yamashita1, Yuto Nakamori1, Arisa Tsukamoto1

  • 1School of Agriculture, Kindai University, Nakamachi, Nara 631-8505, Japan.

Bioorganic & medicinal chemistry
|June 21, 2023
PubMed
概括

新型纳夫托金衍生物被合成并测试为抗增殖和信号传感器和转录-3 (STAT3) 抑制的激活剂. 化合物21显示出显著的活性和STAT3抑制,这表明了潜在的治疗应用.

关键词:
核扩散活动 核扩散活动纳夫托基诺是一种酸盐.它具有抑制STAT3的活性.硫胺是一种硫胺.

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