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Updated: Jul 26, 2025

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
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洛拉提尼布对ALK驱动的耐火性或复发性神经母细胞瘤的安全性和有效性

Yujin Suk1, Sheila K Singh2

  • 1Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada; Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.

Cell reports. Medicine
|June 21, 2023
PubMed
概括

洛拉提尼布在1期研究中对患有复发性或耐火性ALK驱动神经母细胞瘤的儿童显示出有前途,证明了安全性和有效性. 对这种具有挑战性的儿科癌症需要进一步的研究.

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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