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十字植物蔬菜摄入量和前列腺癌风险:系统性审查和元分析
Jiaye Long1, Zhaohui Liu2, Shuai Liang3
1Department of Interventional Radiology, The Second Clinical Medical School of Inner Mongolia University for The Nationalities (Inner Mongolia Forestry General Hospital), Yakeshi, China.
摄入十字花蔬菜与前列腺癌 (PCa) 的风险降低有关. 这次元分析发现摄入量和PCa发生率之间存在显著的反向关系,这表明有保护作用.
科学领域:
- 在瘤学瘤学.
- 营养流行病学 营养流行病学
- 预防医学 预防医学
背景情况:
- 十字花蔬菜消费与前列腺癌 (PCa) 风险之间的联系受到争议.
- 现有的研究对这种关联提出了相互矛盾的发现.
研究的目的:
- 系统地评估十字花蔬菜摄入量与患前列腺癌的风险之间的关系.
- 通过元分析提供对这种关联的定量评估.
主要方法:
- 在主要数据库 (PubMed,Embase,Web of Science,Cochrane Library) 进行了全面的系统文献搜索,直到2022年9月.
- 包括的研究使用Stata 14进行了分析,遵循PRISMA指南.
- 分析协议已在Prospero注册.
主要成果:
- 分析包括7个病例控制和9个队列研究,共计70,201个PCa病例和1,264,437名参与者.
- 较高的十字花蔬菜摄入量与PCa风险降低相关.
- 观察到剂量与反应的关系,每天增加15克的十字花蔬菜与PCa风险下降4.5%相关 (RR:0.955,95%CI:0.928-0.982).
结论:
- 这些发现表明,增加十字花蔬菜的消费可能有助于降低前列腺癌的风险.
- 这支持十字花蔬菜在前列腺癌预防策略中的潜在作用.
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