在强迫症障碍中,证据积累和不确定性的神经相关性
Yi-Jie Zhao1, Yingying Zhang2, Qianfeng Wang2
1Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, China; Zhangjiang Fudan International Innovation Center, Shanghai, China; Department of Psychological Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
概括
患有强迫症 (OCD) 的人在不确定性下表现出受影响的决策,积累更多的证据,但积累速度较慢. 这表明不确定性处理缺陷是强迫症的一个特征,而不是状态因素.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 精神病学是一个精神病学.
背景情况:
- 决策往往涉及在不确定性下承担风险.
- 对不确定性的高度不耐受是强迫症 (OCD) 的一种建议特征.
- 在强迫症中处理不确定性的神经机制和认知构造尚未得到充分理解.
研究的目的:
- 研究强迫症患者的不确定性处理及其神经相关物.
- 区分不确定性处理与使用卡牌博任务处理冲突.
- 检查不确定性处理是否是强迫症的状态或特征.
主要方法:
- 83名参与者 (强迫症患者,强迫症对照组,健康对照组) 在卡牌博任务期间接受了fMRI.
- 一个分层的漂移扩散模型分析了证据积累和决策值.
- 该任务专门通过改变结果差异来测试基于价值的不确定性.
主要成果:
- 强迫症患者表现得更加谨慎,表现较差,证据积累增加,特别是在低不确定性条件下.
- 健康对照组显示,在背部前带状环和前岛中,高低不确定性之间存在神经差异,而强迫症组中没有这种差异.
- 没有发现与囊切除术治疗相关的显著行为或成像差异.
结论:
- 强迫症组表现出不确定性处理受损,特别是在更确定的情况下.
- 在强迫症中,不确定性水平的神经分化受到损害,这表明突出网络功能障碍.
- 障碍不确定性处理似乎是强迫症的认知内因型特征,而不是依赖状态的因素.
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