在女性受试者中,多二与维生素D的相关性
Alexandra E Butler1, Edwina Brennan1, Daniel S Drage2
1School of Medicine, Royal College of Surgeons in Ireland-Medical University of Bahrain, Busaiteen, Bahrain.
Environmental research
|June 21, 2023
概括
聚化双 (PCB) 与非肥胖女性的维生素D水平有一些关联. 然而,这些联系完全可以通过体重指数 (BMI) 来解释,这表明PCB不会直接影响维生素D.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 多双 (PCB) 是已知的内分泌干扰物,可能与维生素D代谢有关.
- 以前的研究表明,较高的体重指数 (BMI) 和PCB水平之间存在反向关系,特别是在非肥胖个体中.
研究的目的:
- 在一组非肥胖女性中,研究多双 (PCB) 与维生素D3 (25(OH) D3) 和活性1,25-二氧维生素D3 (1,25(OH) 2D3) 之间的关联.
- 确定身体质量指数 (BMI) 是否调解了PCB和维生素D代谢产物之间的关系.
主要方法:
- 在58名非肥胖女性中,使用高分辨率气色谱分析了7种指标PCB和总PCB水平.
- 通过同位素稀释液体色谱学并列质谱法量化25[OH]D3和1,25[OH]2D3水平.
- 统计分析包括相关性和多线性回归来评估关联,控制BMI.
主要成果:
- 在总PCB和25(OH) D3之间以及在特定PCB (PCB118,PCB180,PCB153) 和维生素D代谢物之间观察到正相关性.
- 在维生素D缺乏的小组中,总PCB,PCB153和PCB180与25(OH) D3.3.D正相关.
- 多线性回归分析显示,PCB和维生素D代谢物之间的所有观察到的关联都完全由BMI解释.
结论:
- 虽然一些PCB与维生素D代谢物有相关性,但这些关联是由BMI调解的.
- 这些发现表明,PCB积累的不良影响并不是主要由25[OH]D3或1,25[OH]2D3度的变化引起的.
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