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在患有1型糖尿病的儿童和青少年中的角膜共聚焦显微镜异常

Mainak Banerjee¹, Pradip Mukhopadhyay², Shatabdi Ghosh²

¹Department of Endocrinology, Senior Resident, Institute of Post Graduate Medical Education & Research, Kolkata, India.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

|June 21, 2023

概括

角膜共聚焦显微镜 (CCM) 可以检测1型糖尿病 (T1DM) 的儿童的神经损伤,即使没有明显的症状. 这种方法比传统的测试,如热检测值 (TDT) 和神经传导研究 (NCS) 更早地发现神经病变.

科学领域:

眼科医生眼科眼科
神经学神经学
内分泌学在内分泌学.

背景情况:

1型糖尿病 (T1DM) 可以导致糖尿病神经病变,影响大和小的神经纤维.
在儿童T1DM中早期发现神经病变对于预防长期并发症至关重要.
角膜共聚焦显微镜 (CCM) 在无症状或最小症状的T1DM儿童中的实用性尚未得到充分证实.

研究的目的:

评估CCM在检测T1DM儿童和青少年神经病变方面的有效性.
将CCM的诊断性能与热检测值 (TDT) 和神经传导研究 (NCS) 进行比较.

主要方法:

一项队列研究包括51名患有T1DM的儿童和青少年和50名健康对照.
参与者接受了神经评估,包括TDT,NCS和CCM.
多伦多临床神经病症评分被用来评估神经病症症状和症状.

主要成果:

虽然大多数T1DM患者的症状很小,但35%的NCS异常和25.5%的TDT功能障碍.
在49%的T1DM患者中,CCM检测到异常,与异常TDT (92%) 和NCS (88%) 有很高的相关性.
CCM在T1DM患者中发现了小纤维异常,即使正常的TDT (34%) 和NCS (27%).

结论:

角膜共聚焦显微镜 (CCM) 是一种敏感的工具,用于检测儿科T1DM中角膜神经损失.
在T1DM患者中,CCM可以识别神经病变,无论TDT和NCS的发现如何.
CCM为年轻T1DM患者早期神经病变检测提供了一种有价值的方法.

关键词:

孩子们的孩子们的孩子们的孩子们.角膜共聚焦显微镜角膜共聚焦显微镜神经病变是一种神经病变.小纤维损伤的损伤.小纤维的功能障碍.第1类糖尿病 1型糖尿病

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