患有传染性内心炎的患者的静血性疾病正在接受紧急的手术置换 - 重新思考当前的信念
Katarzyna Czerwińska-Jelonkiewicz1, Krzysztof Sanetra2, Piotr P Buszman3
1Division of Cardiology, Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, Krakow, Poland; Adults Intensive Care Unit, Royal Brompton and Harefiled Hospitals, NHS Foundation Trust, London, United Kingdom.
International journal of cardiology
|June 21, 2023
概括
接受手术的感染性内心炎患者的血液静止受损,导致出血并发症. 这项研究强调,需要更好地评估门置换手术前后的血液凝固情况.
科学领域:
- 心血管外科心血管外科
- 血液学 血液学 血液学
- 血栓形成研究研究
背景情况:
- 传染性内心炎 (IE) 是一种独特的血栓炎症状况.
- 凝血病和出血是IE患者手术置换 (SVR) 后常见的早期并发症.
- 在接受SVR的IE患者中,手术周边的静血能力在很大程度上仍然没有特征.
研究的目的:
- 在接受紧急SVR的活跃IE患者中评估周围手术血液静止.
- 为了确定血静性疾病和SVR后早期出血之间的关联.
- 为了研究血静性疾病和早期血栓栓塞事件之间的联系.
主要方法:
- 从2017年12月到2020年1月,在两个中心进行了前性观察性研究.
- 在SVR前24小时和SVR后72小时内使用全血栓形成分析系统 (T-TAS Plus) 评估周围过程血静.
- 包括25名活跃IE患者接受紧急SVR.
主要成果:
- 与正常值相比,IE患者在SVR前和之后的血液静止能力显著受损.
- 通过T-TAS测定评估的血液静止障碍,涉及延长的凝血激活,减少血块形成和血块强度较弱.
- 后SVRT-TAS结果与早期出血和需要输血产品 (红细胞,血小板,新鲜冷血) 的需求有显著的相关性.
结论:
- 接受紧急SVR的活跃IE患者的血液静止能力显著降低.
- 后SVR血静力不足与增加的出血和输血需求有关.
- 该T-TAS Plus系统显示在评估经过SVR的IE患者周围手术静血的潜在实用性.
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