肝细胞癌患病率和治疗结果的种族差异
Vivek Chavda1, Kelsee K Zajac2, Jenna Lynn Gunn2
1Department of Pharmaceutics and Pharmaceutical Technology, L M College of Pharmacy, Ahmedabad, India.
Cancer reports (Hoboken, N.J.)
|June 21, 2023
概括
肝细胞癌 (HCC) 发生率受到遗传突变和非遗传因素的影响,如酒精和病毒性肝炎. 地理位置,性别和种族影响HCC的严重程度和患者的结果.
科学领域:
- 肝病学和瘤学 肝病学和瘤学
- 癌症流行病学 癌症流行病学
- 遗传学和分子生物学
背景情况:
- 肝细胞癌 (HCC) 是全球癌症死亡的主要原因.
- 遗传因素 (例如TP53,CTNNB1突变) 和非遗传因素 (例如酒精,HBV,HCV,NAFLD) 都会导致HCC的发展.
- HCC的发病率和严重程度表现出显著的地理,性别和种族差异.
研究的目的:
- 审查影响肝细胞癌 (HCC) 发生和治疗的流行病学因素.
- 突出基于人口统计和种族的HCC结果的差异.
- 强调需要对HCC进行标准化的评估和治疗指导方针.
主要方法:
- 对肝细胞癌 (HCC) 流行病学现有文献的综述.
- 对HCC的遗传和非遗传风险因素的分析.
- 对人口和种族对HCC进展和生存的影响的检查.
主要成果:
- 诸如TP53和CTNNB1等基因的遗传突变与HCC有关.
- 环境因素,如酒精消费和病毒感染 (HBV,HCV) 是显著的风险因素.
- 与高加索患者相比,非高加索人HCC患者的生存率往往较差.
结论:
- 标准化,基于证据的指导方针对于一致的HCC评估和治疗至关重要.
- 国际合作可以改善肝癌研究和患者的治疗结果.
- 流行病学因素显著影响HCC治疗策略,需要量身定制的方法.
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