糖尿病外围神经病变和维生素B12缺乏之间的双向关联:使用国家样本队列的两个纵向9年后续研究
Heung Yong Jin1, Kyung Ae Lee1, Yu Ji Kim1
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical School, Jeonbuk National University, Research Institute of Clinical Medicine of Jeonbuk National University - Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea.
Primary care diabetes
|June 21, 2023
概括
糖尿病周围神经病变 (DPN) 的风险会随着糖尿病患者的维生素B12缺乏而增加. 甲胺使用显著影响DPN发生率和维生素B12缺乏率,需要进一步调查这些关系.
科学领域:
- 内分泌学和新陈代谢学
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 糖尿病是一种普遍的疾病,与许多并发症有关.
- 糖尿病周围神经病变 (DPN) 是糖尿病的一个常见且令人衰弱的并发症.
- 糖尿病患者经常观察到维生素B12缺乏,可能导致神经病变.
研究的目的:
- 调查甲福明使用,维生素B12缺乏和糖尿病患者中DPN发生之间的联系.
- 检查与维生素B12缺乏相关的DPN发生率.
- 评估DPN和没有DPN的患者中维生素B12缺乏的发生率,并考虑使用甲福林.
主要方法:
- 一个回顾性,倾向匹配的队列研究,利用国家医疗保险服务数据库 - 韩国的全国样本队列.
- 研究1分析了基于维生素B12缺乏状态的DPN发生率.
- 第二项研究分析了基于DPN存在的维生素B12缺乏的发病率,并对甲福林使用进行了比较.
主要成果:
- 患有维生素B12缺乏症的患者中,与没有维生素B12缺乏症的患者相比,DPN发生率更高 (179.7/10000人/年),而不是 (76.6/10000人/年).
- 在维生素B12缺乏的患者中,甲福明的使用显著增加了DPN发生率 (HR:5.76).
- 维生素B12缺乏的发病率在DPN患者 (250.6每10000人年) 和非DPN患者 (129.4每10000人年) 中较高,但甲福林与DPN患者维生素B12缺乏的发病率降低有关 (HR 0.68).
结论:
- 在糖尿病患者中,DPN发生和维生素B12缺乏有关.
- 在研究的队列中,甲胺对DPN发生率和维生素B12缺乏率有截然不同的影响.
- 需要进一步的研究来阐明DPN,维生素B12缺乏和甲胺之间的因果关系.
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