早期 (T1) 阴茎癌生存率的种族差异:来自SEER数据库的分析
Nellowe C Candelario1, Elizabeth Molina1, Maria T Bourlon2
1Division of Medical Oncology, University of Colorado Cancer Center Anschutz Medical Campus, Aurora, CO.
Urologic oncology
|June 21, 2023
概括
种族差异影响早期阴茎癌患者的生存率. 与白人男性相比,患有T1阴茎癌的西班牙裔男性的癌症特异性生存率 (CSS) 较差,这凸显了针对性干预的需要.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 健康差距 研究 研究 研究 研究
背景情况:
- 阴茎癌很罕见,占美国男性癌症的不到1%.
- 早期阶段 (T1) 阴茎癌可能可以通过局部疗法治愈.
- 了解生存结果的种族差异对于公平的护理至关重要.
研究的目的:
- 调查T1阴茎癌癌症癌症特异性生存率 (CSS) 的种族差异.
- 分析影响早期阴茎癌患者CSS的预后变量.
主要方法:
- 利用了SEER-18数据库 (2004-2016) 的数据,用于患有T1,N0,M0阴茎癌的男性.
- 使用Kaplan-Meier分析来评估生存率.
- 进行多变量考克斯回归分析以确定独立的预后因素.
主要成果:
- 总共有1941名患有T1阴茎癌的男性被分析.
- 主要部位手术显著改善了5年的CSS (P <.0001).
- 与白人男性相比,西班牙裔男性的CSS明显差 (HR 1.92;P=.0057);黑人男性的CSS明显差 (HR 1.53;P=.118) 的趋势并不显著.
- 阴茎切除术 (HR 0.45;P=.006) 和阴茎保护手术 (HR 0.25;P<0.001) 都改善了CSS.
结论:
- 对于早期的阴茎癌,CSS存在显著的种族差异.
- 与白人种族相比,西班牙裔种族与更糟糕的CSS有关.
- 在主要部位进行手术干预可以改善T1阴茎癌的生存结果.
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