相关实验视频

Updated: Jul 26, 2025

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound

Published on: March 21, 2025

在前列腺癌查中,多种二次组合测试的临床效用

John V Dudinec¹, Sabrina M Wang¹, Srinath Kotamarti¹

¹Department of Urology and Duke Cancer Institute, Duke University, Durham, North Carolina, USA.

The Canadian journal of urology

|June 21, 2023

概括

同时进行前列腺健康指数 (PHI) 和ExosomeDx前列腺智商 (EPI) 测试可以改善前列腺癌的检测. 综合的阳性结果表明风险更高,可能指导PSA升高的男性的活检决策.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
在瘤学瘤学.
生物标志物研究生物标志物研究

背景情况:

提升的前列腺特异性抗原 (PSA) 需要进一步评估前列腺癌.
结合前列腺健康指数 (PHI) 和ExosomeDx前列腺智商 (EPI) 的临床实用性尚未确定.

研究的目的:

评估PHI和EPI同步测试在男性高PSA的性能.
评估综合生物标志物结果对活检建议和结果的影响.

主要方法:

对162名患者进行PHI和EPI测试的回顾性分析.
根据EPI和PHI的综合阳性/阴性结果,分类成四组.
在不同群体中比较人口统计数据,活检建议和病理学.

主要成果:

同时呈阳性PHI和EPI与75%的前列腺癌检测率有关,其中54.2%是格里森≥7.
在EPI和PHI阳性之间观察到较差的一致性 (科恩卡帕=0.19).
年龄,PSA水平和活检建议在组合测试结果组之间有显著差异.

结论:

同时积极的PHI和EPI结果表明前列腺癌的风险增加.
结合测试可能会影响活检建议和PSA升高的男性的遵守.
进一步的研究是有必要的,以优化这些生物标志物在前列腺癌诊断中的使用.

关键词:

在外基因组Dxx 前列腺健康指数前列腺健康指数生物标志物生物标志物前列腺癌是前列腺癌.查检查查检查查检查查检查

更多相关视频

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy

Published on: April 9, 2019

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

相关概念视频

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...

Sensitivity, Specificity, and Predicted Value

Sensitivity, Specificity, and Predicted Value

In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
Sensitivity is the...

Serum Laboratory Studies, Stool Test, Breath Test

Serum Laboratory Studies, Stool Test, Breath Test

Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...