在韩国年轻发病的2型糖尿病患者中患慢性病的风险
Joonyub Lee1, Seung-Hwan Lee1,2, Kun-Ho Yoon1,2
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Scientific reports
|June 21, 2023
概括
年轻发病的2型糖尿病 (YOD) 患者与晚发病的糖尿病 (LOD) 患者相比,患慢性病 (CKD) 的风险要高得多. 这种增加的风险在非吸烟者中尤为明显,突出显示了针对青少年吸烟者进行有针对性的干预的必要性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 2型糖尿病是慢性病 (CKD) 的主要原因之一.
- 年轻发病的2型糖尿病 (YOD),在40岁之前被诊断出来,可能会带来独特的风险.
- 了解YOD中CKD发病率对于早期干预至关重要.
研究的目的:
- 为了调查患有YOD的患者中患有CKD的风险.
- 为了比较YOD和晚发糖尿病 (LOD) 患者之间的CKD发病率.
- 确定与青年年轻人中CKD发展相关的因素.
主要方法:
- 使用韩国国家医疗保险共享服务数据 (2010-2011) 进行的回顾性队列研究.
- 包括84,384名年龄在20-64岁之间的患者,不包括1型糖尿病和之前的CKD.
- 多变量逻辑回归调整为YOD不同变量.
主要成果:
- 与LOD患者相比,YOD患者患CKD的几率高1.70倍.
- 在YOD中增加的CKD风险在非吸烟者中 (OR2.03) 比吸烟者 (OR1.49) 更大.
- 高血压,脂质失调和硫氨酸尿素使用与YOD患者的CKD有关.
结论:
- 与LOD患者相比,YOD患者患CKD的风险显著增加.
- 早期发病的糖尿病需要积极的CKD查和管理策略.
- 吸烟和并发症等生活方式因素在YOD中CKD进展中发挥作用.
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