氧化-乙氨基与赛莱科西布治疗膝关节全膝关节整形术后膝关节骨关节炎患者的术后疼痛:一项随机对照研究
Yating Li1, Min An1, Yumei Ding1
1Department of Anesthesia, The Second Affiliated Hospital of Inner Mongolia Medical University, No. 59 Kerqin South Road, Hohhot, 010020, China.
Archives of orthopaedic and trauma surgery
|June 21, 2023
概括
氧化-乙氨基在膝关节置换手术后提供了更好的疼痛缓解和患者满意度,相比于celecoxib. 这两种治疗方法在本研究中都显示出类似的安全性.
科学领域:
- 整形外科 整形外科 整形外科
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
背景情况:
- 全膝关节整形术 (TKA) 是膝关节关节炎的常见手术.
- 有效的疼痛管理对于术后恢复和患者满意度至关重要.
- 氧化-乙氨基,一种组合止痛药,以及非类固醇抗炎药物 (NSAID) 赛莱科西布,用于缓解疼痛.
研究的目的:
- 在接受TKA的患者中,比较 oxycodone-acetaminophen 与 celecoxib 的止痛效果和耐受性.
- 为了评估疼痛视觉模拟尺度 (VAS) 评分,患者控制的止痛药 (PCA) 消耗,以及患者的满意度.
主要方法:
- 一项随机对照试验,涉及106名TKA后膝关节骨关节炎患者.
- 患者在手术后的三天内接受了氧化-乙氨基 (5mg/325mg) 或赛莱科西布 (200mg).
- 评估了疼痛VAS得分,PCA使用情况和患者满意度. 还监测了特殊手术医院 (HSS) 的得分和不良事件.
主要成果:
- 氧化-乙氨基组的疼痛VAS分数在休息和曲期间显著降低,与塞莱科克西布组相比 (P <0.050).
- 在氧化-乙氨基组中,总和额外的PCA消耗显著减少 (P < 0.001).
- 在第3天和第7天 (P <0.050) 的氧化-乙氨基组中,患者满意度更高,HSS得分或组间不良事件发生率没有显著差异.
结论:
- 与celecoxib相比,oxycodone-acetaminophen在TKA后期提供更好的疼痛缓解,并提高患者的满意度.
- 氧化-乙氨基的组合在这个患者群体中表现出与塞莱科克西布相似的安全性.
- 这些发现支持氧化-乙氨基作为一种有效的止痛药选择,用于经过全膝关节整形术后的疼痛管理.
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