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膀癌的额外腹膜与腹膜内激进囊切术:一个系统的审查和元分析

Chengyu You¹, Qingchao Li¹, Yongjin Yang¹

¹Department of Urology, Second Hospital of Lanzhou University, Lanzhou, Gansu, China.

Annals of surgical oncology

|June 21, 2023

概括

腹腔外激素囊切除术 (EPRC) 与腹腔外激素囊切除术 (TPRC) 具有类似的瘤治疗结果,但早期并发症较少,特别是胃肠道问题和腹. EPRC显示淋巴细胞的发病率较高,但仍然是一个安全的功能和瘤选择.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
手术瘤学手术瘤学
基于证据的医学基于证据的医学.

背景情况:

激进囊切除术是肌肉侵入性膀癌的标准治疗方法.
额外腹膜外根囊切除术 (EPRC) 和跨腹膜外根囊切除术 (TPRC) 是两种手术方法.
对他们的外科手术和瘤结果进行比较对于外科手术决策至关重要.

研究的目的:

系统地比较EPRC和TPRC的外科和瘤结果.
通过元分析评估EPRC与TPRC的安全性和有效性.

主要方法:

在多个数据库中进行系统的文献搜索 (2022年9月).
八项涉及989名参与者的研究的累积元分析.
遵守PRISMA和AMSTAR指导方针;注册在PROSPERO (CRD42022359322). 在PROSPERO (CRD42022359322). 在PROSPERO (CRD42022359322).

主要成果:

在EPRC和TPRC之间,在操作时间,EBL,LOS或输血方面没有显著差异.
与更短的排气时间和液体吸收时间相关的EPRC.
在EPRC中,早期术后并发症,胃肠道并发症和结节的发病率较低.
与EPRC观察到的术后淋巴细胞发生率较高.
两种方法的瘤结果 (PSM,复发,转移,OS) 都相似.

结论:

EPRC显示了与TPRC相比较的瘤结果.
EPRC与较少的早期术后并发症有关,特别是胃肠道问题和腹膜.
尽管淋巴细胞的风险较高,但EPRC是激进囊切除术的安全有效选择.

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