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Updated: Jul 26, 2025

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
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使用生理学基础的药物动力学建模,根据第一阶段临床数据,对吸入伊特拉科纳的药物相互作用潜力的评估

Mackenzie Bergagnini-Kolev1, Katie Kane2, Ian E Templeton1

  • 1Simcyp Ltd (Division of Certara), Seattle, Washington, USA.

The AAPS journal
|June 21, 2023
PubMed
概括

吸入伊特拉科纳 (PUR1900) 显示药物相互作用风险最小. 基于生理学的药物动力学建模证实了低系统性暴露,减少了对细胞染色体P450 3A4抑制的担忧.

关键词:
过敏性支气管肺炎阿斯伯吉洛斯症囊性纤维化症是什么药物相互作用 药物相互作用这是伊特拉可纳.药物动力学 药物动力学基于生理学的药理动力学.

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