长期治疗抗精神病药物的慢性精神分裂症骨质疏松症的危险因素:一个横截面研究
Furu Liu1, Ying Wu2, Jindong Chen1
1Department of Psychiatry, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central, South University, 410011, Changsha, Hunan, China.
BMC psychiatry
|June 21, 2023
概括
这项研究在精神分裂症患者中确定了低骨矿物密度 (BMD) 的关键实验室风险,包括较低的叶酸和较高的糖化血红蛋白. 研究结果突出了骨质疏松症风险因素中的性别差异,为骨质疏松症预防提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 精神分裂症患者的骨矿物质密度 (BMD) 风险尚不清楚.
- 这项研究调查了精神分裂症 BMD 降低的实验室风险因素.
- 这项研究还评估了这一群体内 BMD 的性别差异.
研究的目的:
- 确定与精神分裂症患者骨矿物质密度 (BMD) 降低相关的特定实验室变量.
- 探索精神分裂症患者中低骨硬度的风险因素的潜在性别特异性差异.
- 为临床识别和预防精神分裂症骨质疏松症提供见解.
主要方法:
- 双能X射线吸收计 (DXA) 用于测量211名精神分裂症患者 (140名男性,71名女性) 的前臂BMD.
- 综合数据收集包括人口统计,临床评估和实验室变量 (营养,荷尔蒙,新陈代谢,炎症标志物).
- 进行了多次回归分析,以确定低BMD的独立风险因素.
主要成果:
- 35%的患者表现出低BMD. 男性的BMDT分数明显低于女性.
- 低BMD的独立风险因素包括较低的叶酸,较高的糖化血红蛋白,年龄较大,较高的血清费里丁和较高的卵泡刺激激素 (FSH).
- 在女性中,BMD与年龄和荷尔蒙 (FSH,丸激素) 相相关;在男性中,它与年龄,微元素 (血清费里,25-OH-VD) 和副甲状腺荷尔蒙有关.
结论:
- 骨质疏松症标志物和精神分裂症之间存在显著的相关性,特别是在实验室发现方面.
- 确定的实验室变量可以作为精神分裂症患者骨质疏松症风险的新指标.
- 研究结果表明,基于特定实验室资料的有针对性的干预措施可以帮助预防骨质疏松症在这个临床群体内.
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