根据时间和肠道养配方对创伤性脑损伤呼吸患者肺部微生物群结构的修改:一项前性随机研究
A Cotoia1, R Paradiso2, G Ferrara3
1Department of Intensive Care, University Hospital of Foggia, Foggia, Italy. antonella.cotoia@unifg.it.
Critical care (London, England)
|June 21, 2023
概括
专业营养可能会影响创伤性脑损伤 (TBI) 患者的肺微生物群. 在TBI患者中观察到肺部微生物群结构的改变,这些患者患有呼吸器相关肺炎 (VAP).
科学领域:
- 关键护理医学 关键护理医学
- 微生物学 微生物学
- 营养科学 营养科学
背景情况:
- 具有免疫营养素的特殊饮食可能有利于急性创伤性脑损伤 (TBI) 患者.
- 专门饮食对调节肺微生物群的作用及其对TBI患者呼吸机相关肺炎 (VAP) 的影响基本上是未知的.
研究的目的:
- 评估特定营养对TBI患者肺部微生物群的影响.
- 分析发病VAP的TBI患者肺微生物组合的变化.
主要方法:
- 31名需要机械通风的TBI患者被随机分为接受专业或标准营养.
- 肺部微生物群多样性 (α和β) 分析来自入院时和ICU后7天的支气管洗 (BAL) 样本.
- 根据VAP的发展,对样本进行了追溯分析.
主要成果:
- 在31名患者中,有10名患者在第一周后发展出VAP.
- 在VAP组中的BAL微生物群显示出β多样性的显著差异,其中增加了Staphylococcus和Acinetobacter属.
- 专业营养对β多样性 (布雷-库蒂斯距离) 具有统计学意义的影响.
结论:
- 患有VAP的TBI患者在入院时和ICU后7天表现出明显的BAL微生物群结构.
- 在肠道配方和微生物群丰富或均之间没有发现相关性.
- 准肺部微生物群是预防重症患者感染的有希望的策略.
关键词:
阿尔法多样性的阿尔法多样性阿尔吉尼因 (Arginine) 是一种素.贝塔多样性 贝塔多样性肺部的微生物群.机械通风机械通风机械通风机欧米茄3和欧米茄3是什么意思专业营养 营养专业营养这是一个TBI,TBI.在VAP中使用VAP.更多相关视频
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