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一种简化方法来纠正动脉输入功能的和,用于心磁共振第一通透输液成像:与同时获得的PET进行验证

Ran Li¹, Masoud Edalati¹, David Muccigrosso¹

¹Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4525 Scott Ave, Room 3114, St. Louis, MO, USA.

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

|June 21, 2023

概括

一种新的简化方法使用MRI准确量化心肌血流 (MBF),克服了动脉输入功能 (AIF) 和问题. 这种技术与PET MBF有很强的相关性,可以更轻松地对 perfusion 成像进行定量分析.

科学领域:

心血管成像 - 心血管成像
医学物理医学物理
放射学放射学是一门学科.

背景情况:

第一次通透输液MRI是为心肌血流 (MBF) 测量而建立的.
动脉输入函数 (AIF) 信号和是准确的MBF量化的一个关键挑战.
¹³N-氨正子发射断层扫描 (PET) 作为MBF测量的参考标准.

研究的目的:

为了验证一种新的,简化的方法来估计AIF从单球体,单序 perfusion MRI.
评估这种简化MRI方法的准确性,以对比PET对MBF量化.
为了使心脏MRI输液数据的定量分析更容易获得.

主要方法:

采用临床全身PET-MRI系统同时对16名心肌缺血患者进行成像.
用于PET输液的N-氨和用于MRI输液的加多对比剂.
模拟MRI AIF和使用玛变量曲线并将成本函数最小化用于估计,将结果与16段AHA模型进行比较.

主要成果:

平均休息时的MBF:PET为1.06 ± 0.34毫升/分钟/克,MRI为1.04 ± 0.30毫升/分钟/克 (P=0.05).
平均应力MBF:PET 2.00 ± 0.74毫升/分钟/克,MRI 2.12 ± 0.76毫升/分钟/克 (P<0.01). 这两种压力均为2.00 ± 0.74毫升/分钟/克.
在PET和MRIMBF (r=0.91,P<0.001) 和心肌 perfusion reserve (r=0.82,P<0.001) 之间存在强烈的线性相关性.

结论:

简化AIF估计方法可用于准确的MBF量化,使用单次序,单注射MRI.
从MRI获得的MBF与同时获得的PETMBF有很强的相关性.
这种后处理技术有助于将临床输液成像转化为定量数据.

关键词:

动脉输入功能的动脉输入功能.心脏磁共振是一种心脏磁共振.心肌动脉的血液流动是如何进行的肌肉心脏的流量储备.血管扩张是一种血管扩张.

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