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Updated: Jul 26, 2025

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

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跨临床试验的全基因组测序确定了与化疗诱导的外围神经病变相关的GPR68的罕见编码变异

Zia Khan1, Min Jung2, Megan Crow2

  • 1Genentech, 1 DNA Way, South San Francisco, 94080, USA. khanz12@gene.com.

Genome medicine
|June 21, 2023
PubMed
概括

对4900名癌症患者的基因分析揭示了GRID2和GPR68的新型变异,与化疗诱导的周围神经病变 (CIPN) 相关. 这一发现为预防这种常见的剂量限制性毒性开辟了新的途径.

关键词:
在CIPN中,您可以使用CIPN.癌症 癌症 癌症 癌症化疗诱导的外围神经病变在 GPR68 中使用.电网2 (GRID2) 是一个电网.神经学毒性 神经学毒性帕克利塔克塞尔是什么?药物基因组学 药物基因组学罕见的编码变体 罕见的编码变体纳税人就是纳税人.整个基因组的测序.

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