便微生物种植改善了的生长性能,通过平衡状Th17/Treg细胞来改善的生长性能
Ziyu Ma1, Muhammad Akhtar1, Hong Pan1
1Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan, 430070, People's Republic of China.
Microbiome
|June 21, 2023
概括
便微生物种移植 (FMT) 通过增加有益的乳酸菌和平衡T辅助细胞17 (Th17) 和调节性T (Treg) 细胞,改善了的生长. 这项研究表明FMT证明了这一点.
科学领域:
- 禽畜科学是一门学科.
- 免疫学 免疫学 免疫学
- 微生物组研究的研究.
背景情况:
- 肠道炎症是生产的一个主要问题,与Th17/Treg细胞失衡有关.
- 肠道微生物群通过调节肠道免疫力和免疫细胞分化,在的生长中起着至关重要的作用.
研究的目的:
- 调查便微生物群移植 (FMT) 是否可以通过重新平衡Th17/Treg细胞来增强的生长.
- 探索肠道微生物群组成和免疫细胞平衡在不同增长性能之间的关系.
主要方法:
- 在使用qPCR和IHC染色的不同体重的的阴中对Th17和Treg细胞标记物 (Stat3, rorγt,IL-6,IL-17A,IL-21, foxp3,TGF-β,IL-10) 的比较分析.
- 从健康的捐赠者移植便微生物群给一天大的小.
- 在FMT后对肠道微生物群组成 (乳酸菌丰富度) 和关键代谢物 (托衍生物) 的分析.
主要成果:
- 体重较低的表现出更高的Th17细胞标记物和较低的Treg细胞标记物,表明存在不平衡.
- FMT显著改善了的生长性能 (P < 0.001).
- FMT 降低了 Th17 标记物和增加了 Treg 标记物 (P < 0.05),同时增加了 Lactobacillus 丰度 (84.98% vs 66.94%) 和特定的托芬代谢物.
结论:
- 不平衡的Th17/Treg细胞会对的生长产生负面影响.
- FMT有效地重塑肠道微生物群,增加乳杆菌和促进Th17/Treg细胞平衡,从而提高的生长性能.
- 类代谢物及其与基受体 (AhR) 途径的相互作用有助于维持免疫平衡.
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