多酶级联触发的氧化释放纳米平台与多药耐药癌症的化疗饥饿类疗法相结合
Ge Li1, Xinyue Lu1, Shixin Zhang1
1Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.
ACS applied materials & interfaces
|June 22, 2023
概括
这项研究介绍了GLDFe/Z-FA,一种新型纳米粒子,通过诱导铁亡和饥饿来打击瘤药物耐药性. 它通过防止药物排放和促进癌细胞死亡来增强化疗效,在体外和体内都有.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 在瘤学瘤学.
背景情况:
- 瘤耐药性仍然是癌症治疗的一个重大挑战.
- 铁死是一种受调节的细胞死亡途径,显示出治疗前景,但在单剂疗效方面面临局限性.
- 协同治疗策略对于克服治疗耐药性至关重要.
研究的目的:
- 开发一种多功能纳米粒子 (GLDFe/Z-FA) 用于协同的癌症治疗.
- 为了研究纳米粒子诱导铁亡,瘤饥饿和增强化疗的能力.
- 为了评估GLDFe/Z-FA在体外和体内对瘤的治疗疗效.
主要方法:
- 制造酸向,合铁的ZIF-8纳米颗粒 (GLDFe/Z-FA) 装载有葡萄糖氧化酶,l-氨酸和 doxorubicin.
- 评估纳米粒子诱导的细胞内葡萄糖,ATP,活性氧物种 (ROS) 和氧化 (NO) 水平的变化.
- 评估铁亡途径诱导,P-糖蛋白抑制,多克索鲁比积累和抗瘤作用.
主要成果:
- GLDFe/Z-FA纳米粒子有效地降低了细胞内葡萄糖和ATP,诱导瘤饥饿.
- 这些纳米粒子产生了ROS和NO,导致化学动力学疗法 (CDT) 和克服耐药性.
- GLDFe/Z-FA诱导铁, significantly in vitro 和 in vivo 显著抑制瘤增殖,并增强了多克索鲁比的细胞毒性.
结论:
- GLDFe/Z-FA纳米粒子代表了协同癌症治疗的有前途的多功能平台.
- 该纳米粒子有效地向癌细胞,诱导瘤饥饿和铁亡,并克服药物耐药性.
- GLDFe/Z-FA显示出抑制瘤进展的巨大潜力,并提供了可行的治疗策略.
关键词:
MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF这里是ZIF-8的位置.化学动力学疗法是一种化学动力学疗法.铁性化 (ferroptosis) 是一种气体疗法是一种气体疗法.多种药物耐药性多种药物耐药性更多相关视频
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