基于多平台综合分析的生物标志物:在绝经前综合征中对--舒进行系统分析
Xinyan Lv1, Qinghua Xu2, Zhiqin Zhang1
1School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, Liaoning, P. R. China.
Journal of separation science
|June 22, 2023
概括
-尼安-舒通过调节酸-3激酶/Akt通路,有效治疗绝经前期综合征. 确定了包括catalpol和paeoniflorin在内的关键生物标志物,提供了对其治疗机制的见解.
科学领域:
- 药理学和中国传统医学
- 生物化学和分子生物学
- 系统生物学 系统生物学
背景情况:
- 尼安舒在临床上有效治疗绝经前综合征,但其活性成分和机制尚不清楚.
- 了解它的作用机制对于优化金神药的治疗潜力至关重要.
研究的目的:
- 阐明在治疗绝经前综合征时使用的根尼安舒的基于机制的生物标志物.
- 确定关键的化学成分及其与治疗途径的相关性.
主要方法:
- 高性能液体染色学-四极飞行时间/质谱学 (HPLC-QTOF/MS) 用于化学成分识别.
- 网络药理学预测主要的调节途径 (酸-3激酶/Akt).
- 多变量分析和皮尔森相关性用于在卵巢切除诱导的绝经前期综合征模型中识别和验证生物标志物.
主要成果:
- 确定了135种化学成分和52种原型血液成分.
- 酸-3激酶/Akt通路被确定为一个关键的调节通路.
- 卡塔尔波尔,ligustilide,paeoniflorin和酸被确定为与治疗途径强烈相关的生物标志物.
结论:
- 尼安舒通过酸-3激酶/Akt通路对更年期前综合征产生治疗作用.
- 卡塔尔波尔,ligustilide,paeoniflorin和酸作为潜在的生物标志物用于Geng-Nian-Shu的疗效.
- 这种多平台的方法为生物标志物的发现和开发提供了一种新的策略,Geng-Nian-Shu.
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