乳腺癌中的HER2内异质性,一个不断发展的概念
Yanjun Hou1, Hiroaki Nitta2, Zaibo Li3
1Department of Pathology and Laboratory Medicine, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, NC 28659, USA.
Cancers
|June 22, 2023
概括
乳腺癌中的人体表皮生长因子受体2 (HER2) 内异质性 (ITH) 与不良结果和对抗HER2疗法的耐药性有关. 需要进一步的研究来澄清HER2 ITH.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 乳腺癌中人类表皮生长因子受体2 (HER2) 的放大或过度表达与预后不佳有关.
- 反HER2向疗法显著改善了HER2阳性乳腺癌患者的治疗结果.
- 复发和远程转移仍然是重大挑战,HER2内异质性 (ITH) 成为潜在的耐药性驱动因素.
研究的目的:
- 审查乳腺癌中HER2 ITH的定义和类型.
- 讨论在存在ITH时解释HER2状态的挑战.
- 探索抗HER2剂在HER2异质乳腺癌中的临床应用.
主要方法:
- 关于乳腺癌中HER2内异质性的当前文献的综述.
- 对HER2状态的诊断挑战和评分方法的分析.
- 对异质病例中抗HER2治疗反应的临床数据的检查.
主要成果:
- HER2 ITH与更差的预后和对抗HER2疗法的耐药性有关.
- 在异质瘤中解释HER2状态带来了重大诊断挑战.
- 在HER2异质乳腺癌中抗HER2药物的疗效需要进一步研究.
结论:
- HER2 ITH是影响乳腺癌治疗反应和预后的关键因素.
- 为了准确的患者分层,需要评估HER2 ITH的标准化方法.
- 数字图像分析可能为异质瘤中的HER2评估提供一种可重现的方法,但其作用需要验证.
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...