受体放射性核素治疗对新生和正常垂体的作用
1Pituitary Tumor Unit, Endocrinology Department, Hospital CUF Descobertas, 1998-018 Lisbon, Portugal.
受体放射性核素疗法 (PRRT) 对侵袭性垂体神经内分泌瘤 (PitNETs) 的疗效有限,只有18%的部分反应和30%的稳定疾病. 当其他治疗方法失败时,PRRT是一种安全的选择.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 核医学是一种核医学.
背景情况:
- 下垂体神经内分泌瘤 (PitNETs) 可能具有攻击性和抗常规治疗能力.
- 对侵略性或转移性PitNETs存在有限的治疗选择,而temozolomide是主要的选择.
研究的目的:
- 审查关于针对侵袭性或转移性PitNETs的受体放射性核素治疗 (PRRT) 的当前数据.
- 评估PRRT在管理这些具有挑战性的瘤中的有效性和安全性.
主要方法:
- 系统审查已发表的病例报告和小系列的PRRT治疗的患者,具有攻击性或转移性PitNETs.
- 对治疗反应的分析,包括部分反应,稳定疾病和进展性疾病.
- 对不良事件的评估和对 pituitary 功能的影响.
主要成果:
- 审查了30名接受PRRT治疗的患者的数据 (23名侵略性PitNET,5名癌症).
- 在有响应数据的27个病例中,18%的患者有部分响应,30%的患者患有稳定疾病,52%的患者患有进展性疾病.
- 一般来说,PRRT是安全的,没有重大不良反应或增加hypopituitarism的风险.
结论:
- 当其他治疗方法失败或不可行时,PRRT可能是攻击性或转移性PitNET的安全选择.
- 瘤缩小发生在多达20%的病例中,约三分之一的病例实现了稳定疾病.
- 需要进一步的研究来确定PRRT在PitNET管理中的作用.
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