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Erden Atilla^1,2, Karim Benabdellah²

¹Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Ave N, Seattle, WA 98109, USA.

|June 22, 2023

概括

采用细胞疗法在治疗复发性/耐药性急性髓性白血病 (AML) 方面面临挑战,原因是患者异质性. 新的策略,如先进的CAR T细胞疗法和向新抗原,对于改善患者反应至关重要.

科学领域:

血液学血液学血液学
免疫学免疫学免疫学
在瘤学瘤学.

背景情况:

与B细胞恶性瘤相比,采用细胞疗法在复发/耐药急性髓性白血病 (AML) 中表现出有限的成功.
目前针对AML的仿真抗原受体 (CAR) T细胞试验的响应率很低 (约. 30%) 和瘤外的毒性.
在AML中,高的患者内和患者间异质性带来了重大治疗挑战.

研究的目的:

审查AML中采用细胞疗法的挑战.
讨论最近的单细胞测序数据,以了解AML异质性.
总结改善AML治疗结果的新策略.

主要方法:

对AML采用细胞疗法的现有文献的审查.
对最近的单细胞测序数据进行分析,以描述AML异质性.
新兴治疗方法和策略的综合.

主要成果:

由于细胞异质性,CAR T细胞和其他AML的采用疗法存在重大挑战.
单细胞测序揭示了AML中DNA,表观遗传,RNA和蛋白质水平的复杂变化.
新的策略为提高疗效和降低毒性提供了潜力.

结论:

为了在AML中有效采用细胞疗法,需要改变范式.
了解AML的细胞生态系统是开发更好的治疗方法的关键.
下一代CAR T,TCR-T,CAR NK和全原方法具有前景.

关键词:

在CAR NK细胞中,在RNAseqqq中使用.T细胞受体T细胞 T细胞急性骨髓性白血病 (AML) 是一种急性骨髓性白血病.细胞疗法细胞疗法仿真抗原 T 细胞的 T 细胞.

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