质瘤患者的功能和结构连接网络的可控性和稳定性
Anke Meyer-Baese1,2, Kerstin Jütten3, Uwe Meyer-Baese4
1Department of Scientific Computing, Florida State University, Tallahassee, FL 32306, USA.
Cancers
|June 22, 2023
概括
质瘤患者表现出大脑网络可控性和强度的改变,特别是在默认模式网络 (DMN) 中. 在IDH野生型患者中,驱动器和关键节点丢失,表明网络解体,而IDH突变患者表现出拓变化和可塑性.
科学领域:
- 神经科学是一个神经科学.
- 计算生物学 计算生物学
- 在瘤学瘤学.
背景情况:
- 由于与大规模神经回路的相互作用,质瘤患者的结构和功能神经网络拓变化超出了瘤部位.
- 了解这些网络变化对于破译质瘤疾病演变至关重要.
研究的目的:
- 分析质瘤患者的结构和功能大脑网络,重点关注默认模式网络 (DMN).
- 为了将网络稳定性和拓特征与患者预后相关联.
- 确定这些网络中的驱动器和关键节点,并评估它们在网络可控性中的作用.
主要方法:
- 对质瘤患者和健康对照者的结构性和功能性大脑网络的分析.
- 确定DMN的网络稳定性和拓特征.
- 驱动节点 (对外部信号敏感) 和关键节点 (对于网络可控性至关重要) 的识别.
- 预后不同的患者组 (IDH突变型与IDH野生型) 和对照组之间的比较.
主要成果:
- 在质瘤患者中,DMN的网络可控性和稳定性下降.
- 在患者中观察到驱动和关键节点的损失,特别是在IDH野生型 (IDHwt) 患者中,这表明潜在的损伤诱导的网络解体.
- 在IDH突变 (IDHmut) 患者中观察到拓变化和关键节点的增加,这表明与瘤生长动态相关的网络可塑性.
结论:
- 质瘤显著影响DMN的可控性和稳健性,在IDHwt和IDHmut亚型之间观察到不同的模式.
- 这些发现突出了基于质瘤亚型和疾病过程的网络解体与可塑性的潜在差异.
- 这项研究引入了一种新的方法,通过神经网络可控性和强度的镜头来探索脑癌的演变.
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