超越CTLA-4和PD-1抑制:用于黑色素瘤治疗的新型免疫检查点分子
Dimitrios C Ziogas1, Charalampos Theocharopoulos1, Panagiotis-Petros Lialios1
1First Department of Medicine, Laiko General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Cancers
|June 22, 2023
概括
针对PD-1和CTLA-4的免疫检查点抑制剂 (ICI) 是有效的黑色素瘤治疗方法. 对LAG-3,TIGIT和TIM-3等新点的研究有可能通过克服耐药性来改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
背景情况:
- 针对PD-1和CTLA-4的免疫检查点抑制剂 (ICI) 是已知的黑色素瘤治疗方法.
- 很大一部分患者表现出对当前ICI治疗的耐药性或早期复发.
- 黑色素瘤免疫规避涉及PD-1和CTLA-4之外的多个免疫检查点.
研究的目的:
- 在黑色素瘤中提供免疫检查点分子的全面概述.
- 在临床前和临床环境中审查针对这些检查点的治疗策略.
- 突出新型ICI组合在改善黑色素瘤治疗结果方面的潜力.
主要方法:
- 对已发表的免疫检查点分子及其点的文献综述.
- 对共抑制和共刺激受体的免疫调节性质的分析.
- 在黑色素瘤治疗中测试的治疗方法的汇编.
主要成果:
- 确定了一些关键的免疫检查点,包括LAG-3,TIGIT,TIM-3,VISTA,IDO1/IDO2/TDO,CD27/CD70,CD39/73,HVEM/BTLA/CD160,以及B7-H3.3.
- 总结了针对这些检查点的治疗方法的临床前和临床数据.
- 强调最近批准的抗LAG-3 ICI (relatlimab) 与尼沃卢马布联合使用.
结论:
- 阻断额外的免疫检查点提供了一个有希望的战略,以克服黑色素瘤的耐药性.
- 新型ICI双重剂,抗体与药物合剂和其他方式正在调查中.
- 了解检查点介导交叉通话对于开发更有效的黑色素瘤免疫疗法至关重要.
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