传输学习深度放射学和手工制作的放射学,用于分类淋巴结从对比增强计算机断层扫描在肺癌中的肺癌
Fabian Christopher Laqua1, Piotr Woznicki1, Thorsten A Bley1
1Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, University of Würzburg, 97080 Würzburg, Germany.
Cancers
|June 22, 2023
概括
机器学习模型可以使用计算机断层扫描 (CT) 扫描来预测肺癌淋巴结阶段,从而减少对正子发射断层扫描 (PET) 扫描的需求. 结合放射学和深度学习功能的混合方法实现了最佳的预测性能.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 医疗成像医学成像
- 机器学习 机器学习
背景情况:
- 定子发射断层扫描 (PET) 是肺癌淋巴结分期的标准,但有局限性.
- 增强对比度的计算机断层扫描 (CT) 是一个更容易获得的替代方案.
- 从CT预测PET结果可以提高分期可访问性.
研究的目的:
- 预测肺癌患者的对比增强计算机断层扫描 (CT) 结果的正子发射断层扫描 (PET).
- 评估不同的特征提取策略,以提高N-分阶段的准确性.
主要方法:
- 100名肺癌患者接受了对比度增强的18F-化氧糖 (FDG) PET/CT.
- 机器学习模型使用放射学功能,EfficientNet-CNN的深度功能以及混合方法进行训练.
- 模型性能被评估使用接收机操作特征曲线 (AUC) 下的面积和缩放的Brier分数 (SBS).
主要成果:
- 一种混合模型结合了放射学和深度特征,实现了最高的性能 (AUC 0.871,SBS 35.8).
- 这种混合方法显著优于仅使用放射学或仅使用深度特征的模型 (p < 0.001).
- 这项研究包括来自100名肺癌患者的2734个淋巴结.
结论:
- 传统的放射学和深度学习功能都为非侵入性肺癌N阶段化提供了有价值的,互补的信息.
- 使用CT衍生功能的机器学习模型可以有效预测PET结果,有助于分期决策.
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