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甲状腺癌和瘤相关免疫细胞在瘤微环境中的交叉声

Mingyuan Song¹, Qi Liu¹, Wei Sun¹

¹Department of Thyroid Surgery, The First Hospital of China Medical University, 155 Nanjing North Street, Shenyang 110001, China.

|June 22, 2023

概括

甲状腺癌 (TC) 免疫疗法正在通过向瘤免疫微环境来推进. 了解甲状腺癌和免疫细胞之间的交叉通话为耐火病例提供了新的策略.

科学领域:

内分泌学在内分泌学.
在瘤学瘤学.
免疫学免疫学免疫学

背景情况:

甲状腺癌 (TC) 是最常见的内分泌恶性瘤,耐火类型带来了重大治疗挑战.
耐火性甲状腺癌,包括耐放射性分化甲状腺癌和厌塑性甲状腺癌,由于治疗方法有限,复发,转移和耐药性,预后不佳.
TC和瘤相关免疫细胞之间的交叉声显著影响瘤进展和转移.

研究的目的:

审查目前对不同类型的TC和免疫细胞之间的交叉通话背后的机制的理解.
总结潜在的免疫疗法策略和与TC中的瘤免疫微环境相关的临床研究结果.
探索最近的进展,以告知个性化治疗策略,并指导新型免疫疗法和TC免疫检查点的开发.

主要方法:

对目前关于甲状腺癌和瘤免疫学的文献进行系统审查.
甲状腺癌细胞和免疫细胞之间的交叉声机制的分析.
评估现有和新兴的免疫疗法策略和临床试验结果.

主要成果:

确定了关键的信号通路和受体相互作用,调解TC-免疫细胞交叉交谈.
突出了瘤免疫微环境在TC进展和治疗耐药性的作用.
总结了有希望的免疫疗法标和正在进行的耐火性TC的临床研究.

结论:

了解TC-免疫细胞相互作用对于开发有效的免疫疗法至关重要.
向瘤免疫微环境为耐火性甲状腺癌提供了新的治疗途径.
对免疫检查点和免疫治疗技术的进一步研究对于改善TC患者的治疗结果至关重要.

关键词:

交叉语音交叉语音交叉语音交叉语音免疫细胞是免疫细胞.免疫疗法免疫疗法甲状腺癌是甲状腺癌.瘤微环境是一个微环境.

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