非酒精性脂肪肝疾病中的肠道微生物群:PREDIMED-Plus试验的子分析
Ana María Gómez-Pérez1,2, Patricia Ruiz-Limón1,2, Jordi Salas-Salvadó2,3,4
1Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, the Biomedical Research Institute of Malaga and Platform in Nanomedicine (IBIMA-BIONAND Platform), University of Malaga, Malaga, Spain.
地中海饮食干预措施显著改变了非酒精性脂肪肝 (NAFLD) 患者的肠道微生物群组成. 这些肠道微生物组变化与肝脏健康标志物的改善相关,强调生活方式.
科学领域:
- 胃肠病学和肝病学 胃肠学和肝病学
- 微生物组研究 微生物组研究
- 营养科学 营养科学
背景情况:
- 非酒精性脂肪肝 (NAFLD) 是与代谢综合征相关的日益严重的健康问题.
- 肠道微生物群失生症越来越多地被认为是NAFLD病原发生的一个因素.
- 生活方式干预,如地中海饮食,在管理NAFLD方面表现有前途.
研究的目的:
- 调查肠道微生物群变化与NAFLD的生化标志物之间的关系.
- 评估地中海饮食干预措施对肠道微生物组成的影响.
- 为了将肝硬化指数 (HSI) 和纤维化-4 (FIB-4) 评分的变化与特定的肠道细菌相关联.
主要方法:
- 从PREDIMED-Plus试验中对297名参与者的肠道微生物组合进行分析.
- 在地中海饮食干预一年后,根据HSI和FIB-4分数的变化,将参与者分类为三级动物.
- 在不同纤维化风险群体 (NSF与SF) 之间的微生物丰度的比较和变化.
主要成果:
- 在基线和一年干预之间观察到肠道微生物群的显著差异,特别是在极端的HSI变化三位体 (T1和T3) 中.
- 与那些怀疑有纤维化 (SF) 的人相比,患有非可疑纤维化 (NSF) 的参与者表现出不同的微生物特征.
- 特定的细菌种群,包括Akkermansia,Desulfovibrio,Enterobacteriaceae,Sutterella,Faecalibacterium和Blautia,显示了与HSI和FIB-4得分修改相关的显著变化.
结论:
- 基于地中海饮食的生活方式干预可以调节NAFLD患者的肠道微生物群组成.
- 肠道微生物特征的变化与NAFLD生化标志物 (HSI和FIB-4) 的改善有关.
- 这些发现强调了肠道微生物群在治疗NAFLD和代谢综合征中的作用.
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