相关实验视频

Updated: Jul 26, 2025

Methyl-binding DNA capture Sequencing for Patient Tissues

Methyl-binding DNA capture Sequencing for Patient Tissues

Published on: October 31, 2016

在子宫内膜癌组织中,PTEN促进剂甲基化和表达

Fatemeh Khatami¹, Shadab Shahriari², Soheila Aminimoghaddam³

¹Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

|June 22, 2023

概括

在子宫内膜癌中,PTEN基因表达显著降低,这是由于促进剂高甲基化. 这种表观遗传变化在瘤组织中比正常组织更频繁地观察到.

科学领域:

在瘤学瘤学.
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
分子生物学分子生物学

背景情况:

表观遗传修饰,如DNA甲基化,在调节各种癌症中的基因表达方面发挥着至关重要的作用.
酸酶和张素同类基因 (PTEN) 是一种参与细胞生长和存活的瘤抑制剂,其失调与癌症发展有关.

研究的目的:

为了研究PTEN促进物甲基化和PTEN基因表达在子宫内膜癌中的关系.
确定PTEN促进物甲基化是否是子宫内膜癌组织中常见的表观遗传事件.

主要方法:

在39个子宫内膜癌组织和41个正常子宫内膜组织中使用实时PCR分析PTEN基因表达.
使用化敏感高分辨率化 (MS-HRM) 分析在瘤和非瘤组织的子集中量化PTEN促进剂甲基化.

主要成果:

与正常组织相比,子宫内膜癌组织中PTEN基因表达显著下降.
在瘤组织中,PTEN促进物甲基化显著高于非新生体组织 (13.6%),而不是瘤组织 (52.0%).
在PTEN表达或甲基化与子宫内膜癌患者的临床病理特征之间没有发现显著的相关性.

结论:

在子宫内膜癌中,PTEN基因表达的降低与其促进物高甲基化有关.
PTEN促进剂高甲基化是子宫内膜癌中经常发生的表观遗传变异,这表明它在瘤发生中的潜在作用.

关键词:

人力资源经理人力资源管理员在这里,我们可以使用PTEN.这是子宫内膜癌的癌症.表达方式表达方式表达方式高分辨率的融技术甲基化处理的方法

更多相关视频

Non-Invasive Ultrasound Assessment of Endometrial Cancer Progression in Pax8-Directed Deletion of the Tumor Suppressors Arid1a and Pten in Mice

Non-Invasive Ultrasound Assessment of Endometrial Cancer Progression in Pax8-Directed Deletion of the Tumor Suppressors Arid1a and Pten in Mice

Published on: February 17, 2023

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

相关概念视频

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...