在聚合物外科网状表面上对含银的玻璃陶抗菌涂层进行非破坏性加工
Amin Zareei1,2, Venkat Kasi1,2, Allison Thornton1,2
1School of Materials Engineering, Purdue University, West Lafayette, IN 47907, USA. rrahimi@purdue.edu.
Nanoscale
|June 22, 2023
概括
这项研究引入了一种新的方法,用抗菌银纳米颗粒涂覆聚烯外科手术网,使用冷大气等离子体和激光处理. 这项创新旨在减少外科手术网状感染并改善修复结果.
科学领域:
- 生物材料科学 生物材料科学
- 医疗设备工程 医疗设备工程
- 纳米技术 纳米技术
背景情况:
- 聚烯手术网格对于的修复至关重要,但容易患上术后感染,增加复发风险.
- 抗生素涂层由于抗生素耐药性细菌的增加而变得越来越低效.
- 含有银纳米粒子 (AgNPs) 的生物活性玻璃陶对抗菌性质有希望,但需要高温,不适合聚合物网格.
研究的目的:
- 开发一种用于将含有AgNP的生物活性玻璃陶涂层沉积在温度敏感聚烯网 (PP-M) 上的新方法.
- 优化激光表面处理 (LST) 条件,以有效地形成玻璃陶,而不会损害PP-M的性能.
- 评估开发的涂层的生物相容性和抗菌疗效.
主要方法:
- 使用冷大气等离子体 (CAP) 进行SiO2薄膜沉积.
- 在PP-M上采用激光表面处理 (LST) 来选择性加热和形成玻璃陶化合物.
- 系统地改变LST参数以确定最佳条件.
- 评估了PP-M化学和机械性能的变化 (目标<1%的变化).
- 测试了7天以上的涂层生物相容性和抗菌活性,对抗格拉姆阳性和格拉姆阴性细菌.
主要成果:
- 确定了在PP-M上创建生物活性玻璃陶结构的最佳LST条件.
- 在PP-M基板的化学和机械性能中显示出最小的变化 (<1%).
- 对广泛的细菌产生持久的抗菌疗效 (>7天).
- 确认了功能化网格的高生物相容性.
结论:
- 使用CAP和LST的新型低温方法使功能生物活性玻璃陶涂层能够沉积在聚烯网上.
- 开发的涂层有效地对抗细菌感染,并保持网状网状的完整性,为减少修复并发症提供了一个有希望的解决方案.
- 这种方法为在不同的可植入器件上应用各种生物陶涂层铺平了道路,提高了它们的安全性和性能.
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