基于曼尼托尔的减少体积水分对功能的影响,同时基于思普拉丁的化学辐射治疗头角状细胞癌
Christopher Paschen1,2, Matthias Moll2, Gabriela Altorjai2
1Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Head & neck
|June 22, 2023
概括
在头癌患者中,使用曼尼托尔的短时间补水减少了急性损伤 (AKI) 和增加了西斯剂量. 女性患者经历了更高的AKI风险.
科学领域:
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床药房 临床药房
背景情况:
- 基斯普拉丁基化学辐射是治疗头角状细胞癌 (HNSCC) 的标准治疗方法.
- 毒性是西斯普拉丁化疗的常见且显著的副作用.
- 优化补水策略对于减轻西斯普拉丁诱导的损伤至关重要.
研究的目的:
- 评估部门水化政策变化对HNSCC患者毒性和化疗剂量的影响.
- 为了比较常规水合 (CH) 和使用曼尼托尔 (SHM) 进行较短的水合之间的结果.
主要方法:
- 对HNSCC患者的回顾性时间序列分析.
- 对接受CH (01/2017-09/2018) 与SHM (09/2018-08/2019) 的患者进行比较.
- 评估急性损伤 (AKI) 率和累计获得的西斯普拉丁剂量.
主要成果:
- 与常规水化 (CH) 相比,使用曼尼托尔 (SHM) 进行较短的水化与明显较低的AKI (54.3%与74.4%) 和更高的达到青剂量目标率 (82.9%与61.5%) 相关.
- 严重的AKI (≥2级) 与SHM显著较低 (2.9%与22.8%相比).
- 女性患者呈现较高的AKI发病率 (92.6%对60.5%),并获得较低的累积西斯普拉丁剂量 (51.9%对73.3%).
结论:
- 在HNSCC化学辐射中使用曼尼托尔进行更短的水合,可以减少AKI,并允许更高的化疗输送.
- 女性患者代表了一个脆弱的群体,在西斯普拉丁治疗期间需要对AKI进行更密切的监测.
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