一种罕见的自身免疫性肠病变,与自身免疫性肝炎相关
Francisca Correia1, Isabel Garrido2, Vanessa Chaves3
1Internal Medicine Department, Centro Hospitalar e Universitário de São João, Porto, Portugal. afranciscaazevedocorreia@gmail.com.
Journal of gastrointestinal and liver diseases : JGLD
|June 22, 2023
概括
本案例研究呈现了第一例与自身免疫性肝炎同时诊断的自身免疫性肠道病变. 用普雷迪尼索隆和阿扎西奥普林治疗导致患者显著改善.
科学领域:
- 胃肠病学 胃肠病学
- 肝病学 肝病学是一种肝病学.
- 免疫学 免疫学 免疫学
背景情况:
- 自身免疫性肠病 (AIE) 和自身免疫性肝炎 (AIH) 分别是不同的免疫媒介胃肠道和肝脏疾病.
- 同时诊断AIE和AIH是罕见的,报告的病例有限.
- 这项研究突出展示了AIE和AIH同时进行的独特演示.
研究的目的:
- 报告第一个被诊断为同时患有自身免疫性肠病和自身免疫性肝炎的患者的记录病例.
- 描述这种罕见的双重诊断的临床表现,诊断发现和治疗结果.
- 强调在复杂的胃肠道表现中考虑重叠的自身免疫疾病的重要性.
主要方法:
- 一个全面的诊断方法,包括临床评估,血液测试 (肝功能测试),囊内镜和小肠粘膜活检.
- 小肠活检的组织病理学检查,以评估粘膜缩,密室增生和淋巴管切除.
- 应用了自身免疫性肠病和自身免疫性肝炎的诊断标准.
主要成果:
- 该患者出现了慢性体重减轻,腹痛和腹,以及肝酶升高,胆固醇衰竭和高白血症.
- 囊内镜检查显示了广泛的淋巴管切除,缩短的小,以及小肠的侵蚀.
- 组织病理学证实了严重的粘膜缩和密室增生,与自身免疫性肠道病变一致. 同时诊断出自身免疫性肝炎.
- 患者对使用普雷迪尼索隆和阿扎西奥普林的免疫抑制疗法反应良好.
结论:
- 该病例代表了首次报告的同时诊断自身免疫性肠病变和自身免疫性肝炎的情况.
- 这些发现强调了自身免疫性胃肠道和肝脏疾病的潜在重叠.
- 及时诊断和联合免疫抑制疗法可以在同时患有AIE和AIH的患者中带来显著的临床改善.
相关概念视频
01:17Gastritis-II: Pathophysiology
382
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
382
01:29Autoimmune Disorders
526
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
526
01:17Chronic Bowel Disorders: Introduction
490
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
490
01:24Chronic Pancreatitis I: Introduction
116
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
116
01:27Gastritis-I: Introduction and Types
573
Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
573
01:26Diseases of the Liver and Gallbladder
674
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
674