通过预防阴茎氧化损伤和调节暴露大鼠的循环丸激素来改善性表现和勃起功能
Elizabeth Enohnyket Besong1, Tunmise Maryanne Akhigbe2,3, Precious Jesutofunmi Ashonibare3,4
1Department of Physiology, Faculty of Basic Medical Sciences, Ebonyi State University, Abakaliki, Nigeria.
Redox report : communications in free radical research
|June 22, 2023
概括
补充剂改善了诱导的男性性和勃起功能障碍. 它通过减少氧化应激和激活保护通路来增强生殖激素和阴茎功能.
科学领域:
- 毒理学 毒理学 毒理学
- 生殖生物学 生殖生物学
- 营养科学 营养科学
背景情况:
- 暴露于是一种已知的环境毒素,影响男性生殖健康.
- 性和勃起功能障碍是与重金属毒性相关的重大问题.
研究的目的:
- 研究治疗对雄性大鼠的诱导性和勃起功能障碍的保护作用.
- 阐明治疗作用的基本机制.
主要方法:
- 雄性Wistar大鼠被分为对照组,治疗组,暴露组和+治疗组.
- 治疗方法是每天口服,持续28天.
- 评估性行为,阴茎功能,荷尔蒙水平和阴茎组织中的生化标志物.
主要成果:
- 同时服用可显著改善性行为和暴露大鼠的勃起功能.
- 治疗使氧化 (NO),循环氨酸单酸盐 (cGMP),和其他生殖激素的水平正常化.
- 减轻了氧化应激标志物 (山丁氧化酶,尿酸,) 和增强了抗氧化防御 (Nrf2,GSH,SOD,GPx,GST).
结论:
- 补充剂有效地改善了引起的性和勃起功能障碍.
- 通过抑制氧化应激和通过依赖Nrf2的信号通路调节丸激素来介导保护作用.
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