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使用基于双导航器的GRASE进行3D扩散MRI,并与2DEPI进行对人类大脑道图的比较

Haotian Li¹, Tao Zu¹, Ruike Chen¹

¹Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.

Magnetic resonance in medicine

|June 22, 2023

概括

使用双导航器的新3D扩散MRI序列改善了信号噪声比 (SNR) 并纠正全脑成像的相位错误. 与传统的2D方法相比,这种先进的技术增强了纤维跟踪和微结构映射.

科学领域:

磁共振成像是一种磁共振成像技术.
神经成像是一种神经成像.
生物医学工程生物医学工程

背景情况:

三维 (3D) 脉冲序列提供高分辨率和信号噪声比 (SNR),但由于相位错误,在扩散MRI (dMRI) 中面临挑战.
在dMRI中扩散编码引入了额外的相位错误,使高质量的3D采集复杂化.

研究的目的:

开发和评估基于双导航器的3D扩散加权梯度旋转回声 (GRASE) 序列,用于全脑dMRI.
为了纠正在多次射击dMRI采集中固有的相位错误.
将拟议的3D GRASE序列的性能与2D同时多切片EPI进行比较.

主要方法:

提出了一种基于双导航器的3D扩散加权的GRASE序列,用于人类全脑获取.
在相同的采集时间内比较3D GRASE和2D同时多切片EPI之间的SNR.
评估了纤维跟踪和微结构映射,使用扩散张力和高阶纤维定向密度指标来进行2D与3D采集.

主要成果:

双导航器方法在全脑dMRI中有效地减少了多次射击相位错误,2D导航器的性能优于1D导航器.
在相同的扫描时间内,3D GRASE 序列实现了比 2D EPI 高出 1.4-1.5 倍的 SNR.
与2D EPI相比,3D GRASE揭示了大脑脊髓道中较大的纤维截面和更丰富的皮层下U纤维.

结论:

基于双导航器的3DdMRI-GRASE序列有效地减少相位误差,并增强全脑成像的SNR.
2D和3D采集之间的纤维跟踪和微结构映射的差异突出了3D方法的优点,可能是由于改进了切片配置文件.

关键词:

三维草地3D草地基于Fixel的分析微结构地图的绘制.这是一个相位错误的错误.双胞胎导航员导航员双胞胎导航员

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Magnetic Resonance Imaging

Magnetic Resonance Imaging

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