在多种族和多民族的HIV+队列中获得心血管疾病的蛋白质风险评分
Sandra E Safo1, Lillian Haine1, Jason Baker2
1University of Minnesota Minneapolis MN USA.
Journal of the American Heart Association
|June 22, 2023
概括
一个新的蛋白质生物标记得分可以帮助预测艾滋病毒感染者 (PLWH) 心血管疾病 (CVD) 风险. 这个得分,使用8种蛋白质,识别需要积极的降低风险策略的个体.
科学领域:
- 生物标志物和诊断方法
- 心血管健康 心血管健康
- 艾滋病毒研究 艾滋病毒研究
背景情况:
- 现有的心血管疾病 (CVD) 风险预测模型不充分评估艾滋病毒感染者 (PLWH) 的风险.
- 在PLWH人群中,急需改善心血管疾病风险分层.
研究的目的:
- 开发一种新的风险评分,利用蛋白质生物标志物来预测PLWH中的心血管疾病.
- 提高艾滋病毒感染者心血管疾病风险评估的准确性.
主要方法:
- 一项匹配的病例控制研究分析了INSIGHT试验参与者的蛋白质表达数据.
- 尺寸缩小,变量选择和多变量逻辑回归确定了候选蛋白质生物标志物.
- 一个蛋白质得分被生成并使用引导方法内部验证.
主要成果:
- 来自8种蛋白质的蛋白质评分,包括肝细胞生长因子 (HGF) 和介质蛋白-6,与心血管疾病风险增加有关 (OR:2.17).
- 与单个蛋白质生物标志物相比,蛋白质得分显示出更好的心血管疾病预测能力.
- 蛋白质分数高于中位数的个体患心血管疾病的可能性超过3倍 (OR:3.10).
结论:
- 一组血液蛋白质生物标志物可以识别患有心血管疾病高风险的艾滋病毒感染者.
- 这一经验证的得分可以补充PLWH中针对性降低心血管疾病风险的现有因素.
- 这些发现可能有助于了解PLWH群体中心血管疾病的发病因子.
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