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关于益生菌补充剂在婴儿阿托皮性皮肤炎中的预防和治疗效果的元分析

Husein Husein-ElAhmed^1,2, Martin Steinhoff^2,3,4,5,6

¹Department of Dermatology and Venereology, Hospital de Baza, Granada, Spain.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

|June 22, 2023

概括

益生菌补充剂可以降低亚托皮炎 (AD) 的发生率. 像L. paracasei和L. sakei这样的特定菌株显示出最有前途的预防方法,特别是当给予母亲时.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
皮肤病学皮肤病学

背景情况:

有矛盾的证据表明,益生菌对阿托皮性皮肤炎 (AD) 的疗效.
需要进一步的研究来澄清益生菌在AD预防和治疗中的作用.

研究的目的:

系统地评估益生菌补充剂对AD发病率和严重程度的影响.
为了确定最有效的特定益生菌菌株和给药时间.

主要方法:

在三个数据库中进行系统搜索.
对研究分析研究的分析研究对AD进行益生菌的管理.
发病率的评估,SCORAD (SCORing Atopic Dermatitis) 和IDLQI的结果. 这是一个很好的方法.

主要成果:

益生菌使用与阿尔茨海默病发病率降低22%有关.
对孕妇/哺乳期母亲和婴儿的使用显示出显著的发病率降低 (49-39%).
L. paracasei和L. sakei在SCORAD中表现出最大的减少,而L. rhamnosus是无效的.

结论:

益生菌对阿尔茨海默病的预防是有效的,特别是在怀孕和哺乳期间通过母亲的摄入.
对于益生菌治疗阿尔茨海默氏症的证据,特别是在1岁以下的婴儿中,不那么有说服力.
L. paracasei和L. sakei是AD预防的有希望的菌株.

关键词:

益生菌益生菌益生菌免疫学免疫学免疫学儿童类亚托邦性皮肤炎预防预防预防治疗治疗治疗治疗治疗治疗

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