使用单颗粒ICP-TOFMS对Pt纳米粒子进行表征的实验室间比较结果
Lyndsey Hendriks1, Robert Brünjes2, Sara Taskula2
1TOFWERK AG, Thun, Switzerland. lyndsey.hendriks@tofwerk.com.
Nanoscale
|June 22, 2023
概括
这项研究验证了纳米粒子单颗粒ICP-TOFMS分析的标准操作程序. 颗粒质量测量显示实验室之间有很好的一致性,而颗粒数度结果更有变化.
科学领域:
- 分析化学 分析化学
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
背景情况:
- 单粒子感应合等离子体飞行时间质谱法 (sp-ICP-TOFMS) 的标准化对于可靠的纳米粒子表征至关重要.
- 视野2020项目ACEnano的目标是开发和验证纳米材料的先进分析方法.
- 实验室间比较 (ILC) 对于评估不同实验室分析方法的稳定性和可重复性至关重要.
研究的目的:
- 评估和验证sp-ICP-TOFMS的标准操作程序 (SOP).
- 通过涉及9个实验室的实验室间比较 (ILC) 来评估SOP的性能.
- 关于粒子质量,数量度和同位素组成的纳米粒子 (Pt NP) 悬浮物的特征.
主要方法:
- 使用验证的标准操作程序 (SOP) 进行了实验室间比较 (ILC),用于单粒子感应合等离子体飞行时间质谱 (sp-ICP-TOFMS).
- 九个实验室参与,使用icpTOF仪器测量了两个不同的纳米粒子 (Pt NP) 悬浮液.
- 描述侧重于粒子质量,粒子数度和同位素组成.
主要成果:
- 两个Pt NP样本的质量等价球形尺寸 (MESS) 确定了良好的实验室间协议 (<16% RSD,异常排除后<4%).
- 颗粒数度测量显示出更高的可变性 (<53% RSD),与之前的ICP-MS实验室间研究一致.
- 对于同位素比率的确定,获得了高精度 (强度比率为194Pt和195Pt的<1%),精度仅限于计算较少同位素的统计数据.
结论:
- 为sp-ICP-TOFMS开发的SOP已被验证用于粒子质量测定,在实验室之间显示出良好的可重复性.
- 虽然粒子数度测量需要进一步优化,但该方法显示了粒子密度测定的潜力.
- ICP-TOFMS在多同位素分析方面表现出色,为主要同位素比率提供了高精度,并为纳米粒子的先进同位素表征铺平了道路.
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