接种疫苗可以预防1型干扰素自抗体中和患者的严重COVID-19结果
Anette S B Wolff1,2, Lena Hansen2,3, Marianne Aa Grytaas1
1Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway.
iScience
|June 22, 2023
概括
患有自身免疫多分泌综合征1型 (APS-1) 的患者获得了足够的SARS-CoV-2疫苗反应. 接种疫苗保护了APS-1患者免受严重的COVID-19,尽管对1型干扰素 (IFN-I) 有自身抗体.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
背景情况:
- 自免疫多分泌综合征1型 (APS-1) 具有针对1型干扰素 (IFN-I) 的自身抗体的特征.
- 这些IFN-I自身抗体与严重的COVID-19结局有关.
- 接种SARS-CoV-2疫苗对APS-1患者的影响尚不清楚.
研究的目的:
- 为了评估SARS-CoV-2疫苗耐受性和APS-1患者的免疫反应.
- 在这个队列中评估接种疫苗对随后的SARS-CoV-2感染的有效性.
- 了解IFN-I自身抗体如何影响APS-1中的疫苗疗效和感染严重程度.
主要方法:
- 一组33名成年APS-1患者接受了SARS-CoV-2疫苗接种.
- 在接种疫苗后测量了SARS-CoV-2尖端特异性抗体水平.
- 免疫反应和耐受性与年龄和性别匹配的健康对照进行了比较.
- 随后的SARS-CoV-2感染和疾病严重程度受到监测.
主要成果:
- APS-1患者在接种疫苗后表现出足够的SARS-CoV-2尖端特异性抗体反应.
- 在APS-1队列中没有观察到疫苗耐受性下降.
- 抗体反应的峰值低于健康对照组,类似于老年人.
- 与年轻对照组相比,APS-1患者的抗体水平下降得更快,但比老年人慢.
- 疫苗接种在SARS-CoV-2感染后提供了对严重疾病的保护.
结论:
- 接种SARS-CoV-2疫苗耐受性良好,并且在APS-1患者中引起保护性免疫反应.
- 疫苗接种有效地减轻了APS-1中严重COVID-19的风险,取代了IFN-I自身抗体的负面影响.
- 这些发现支持对患有APS-1的个体进行SARS-CoV-2疫苗接种的建议.
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