系统性红斑狼和心血管疾病:一个系统性审查
Mohammed A Nor1, Oboseh J Ogedegbe2, Ahmed Barbarawi3
1Internal Medicine, Stamford Hospital/Columbia University Vagelos College of Physicians and Surgeons for Internal Medicine, Stamford City, USA.
Cureus
|June 22, 2023
概括
系统性红斑狼 (SLE) 显著增加心血管疾病 (CVD) 的风险,包括心脏病发作和动脉样硬化. 这一综述证实了SLE与各种心脏病之间的强烈联系,强调了需要进一步研究的必要性.
科学领域:
- 风湿病学和心脏病学
- 自免疫性疾病 自免疫性疾病
- 心血管健康 心血管健康
背景情况:
- 系统性红斑狼 (SLE) 是一种复杂的自身免疫性疾病,涉及多个器官.
- 在SLE患者的心血管并发症往往表明预后较差.
- 现有的文献缺乏关于SLE与心血管疾病相关性的全面系统审查.
研究的目的:
- 系统地审查和分析SLE与心血管疾病 (CVD) 之间的关联.
- 评估与非SLE患者相比,SLE患者患心肌梗塞 (MI) 和动脉样硬化等特定心血管疾病的风险.
主要方法:
- 根据PRISMA指南进行了系统审查.
- 在PubMed,Google Scholar和Cochrane数据库中搜索了2003年3月至2023年3月期间发表的文章.
- 包括8项研究 (2篇叙述性评论,2篇系统性评论,4篇观察性研究) 经过严格选.
主要成果:
- 证实了SLE与广泛的心血管疾病之间的强烈关联,包括罕见的疾病,如血管炎和大动脉剖析.
- 所有选择的研究都表明SLE和心血管疾病之间存在联系.
- 最近的研究始终表明,在SLE患者中,外周动脉封闭性疾病 (PAOD),心脏病发作,心周炎,心肌炎和其他心血管问题的风险较高.
结论:
- 系统性红斑狼明确影响心脏,并与各种心血管疾病密切相关.
- 患者的特征和并发症影响疾病的严重程度和预后,表明复杂的相互作用.
- 更大规模的研究至关重要,以进一步阐明这种关系和潜在的病原发生因,以改善患者的治疗结果.
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