在受孕和早孕时触发多发性硬化症:紫外线辐射的变化与其强度同样重要
George E Davis1, Matthew J Davis1, Walter E Lowell1
1Riverview Psychiatric Center, 250 Arsenal Street, State House Station #11, Augusta, ME, 04333-0011, USA.
Heliyon
|June 22, 2023
概括
怀孕的月份,而不是出生,是紫外线辐射 (UVR) 和维生素D的关键.
科学领域:
- 环境科学 环境科学
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 多发性硬化症 (MS) 发病率正在上升,不成比例地影响女性和非裔美国人.
- 紫外线辐射 (UVR),地理度和维生素D在MS病变发生中的作用需要进一步阐明.
- 现有研究强调,需要探索环境因素和MS等自身免疫性疾病之间的复杂相互作用.
研究的目的:
- 调查紫外线暴露,地理度和多发性硬化症 (MS) 的发展之间的关系.
- 探讨紫外线的变化,特别是在受孕期间,影响维生素D-VDR通路和MS倾向的假设.
- 通过检查环境触发因素和遗传易感性,提供MS病因学的新视角.
主要方法:
- 从缅因州中部的一个天文台收集了15年的紫外线数据 (2007-2021年).
- 每月计算UVR (CVUVR) 的平均变化系数.
- 分析了怀孕月 (MOC) 与出生月 (MOB) 对MS风险的影响.
主要成果:
- 怀孕月 (MOC) 比出生月 (MOB) 在UVR如何影响MS遗传倾向方面更为关键.
- 从8月到12月增加CVUVR可能会阻碍维生素D受体 (VDR) 活性,从而需要在以后的生活中提高UVR以抑制免疫系统,从而增加MS风险.
- 一个新的概念表明,UVR在MS中的作用与受孕时间和VDR调制有关.
结论:
- 高紫外线强度,特别是在受孕期间,可以压倒维生素D-VDR机制,导致基因毒性作用,促进遗传敏感个体的MS.
- 紫外线,受孕时间和维生素D代谢之间的相互作用是MS发展的关键因素.
- 这项研究引入了一个关于多发性硬化症的环境和遗传基础的新假设.
更多相关视频
06:09Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
Published on: June 7, 2019
8.8K
09:09Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
Published on: August 17, 2022
1.7K
相关概念视频
Mutations
38.3K
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
38.3K
Spontaneous and Induced Mutations
45
Spontaneous mutations arise infrequently during DNA replication due to errors in the process. A key factor behind these errors is tautomeric shifts in nitrogenous bases, where bases transition from keto to enol forms or amino to imino forms. This shift can alter base-pairing rules, leading to mutations. Additionally, reactive oxygen species (ROS) arising from aerobic metabolism can damage DNA, resulting in depurination (loss of a purine base) or depyrimidination (loss of a pyrimidine base).
45
Meiosis vs. Mitosis
57.2K
Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
57.2K
Teratogenicity
2.5K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.5K
Skin Cancer
4.2K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.2K
Nucleotide Excision Repair
3.6K
DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
3.6K
