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Celastrus Paniculatus种子提取物对和相关认知缺陷的神经保护作用
Arti Ralta1, Ajay Prakash1, Praveen Kumar M1
1Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Basic and clinical neuroscience
|June 22, 2023
概括
塞拉斯特鲁斯 (Celastrus paniculatus) 种子提取物在减少发作的严重程度和改善类诱导的模型中的认知缺陷方面显示出有希望. 这种天然提取物,单独或与其他药物结合,也可以防止神经元损失.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 生物化学 生物化学
背景情况:
- 经常伴随着认知缺陷.
- 乙 (PTZ) 诱导的化学点火模型是研究和相关并发症的标准方法.
- 焦虑 (Celastrus paniculatus) 是一种具有传统药用历史的植物.
研究的目的:
- 评估Celastrus paniculatus种子提取物在减轻PTZ诱导化学点火模型中的发作严重程度和认知障碍方面的疗效.
- 为了研究C. paniculatus的神经保护和抗氧化作用.
主要方法:
- 在动物中建立了一个PTZ诱导的化学点火模型.
- 动物接受了C. paniculatus提取物,甲酸 (SVA),甲或其组合的治疗.
- 进行了神经行为测试 (莫里斯水迷宫,握力测试),生化测试 (抗氧化剂标志物,多巴胺水平) 和组织学分析 (H&E染色).
主要成果:
- 单独使用C. paniculatus和与SVA或百戈利德结合使用,显著降低了发作得分,并在莫里斯水迷宫中提高了性能.
- 生物化学分析显示,抗氧化剂标记物 (GSH,CAT,SOD) 和多巴胺的水平较高.
- 组织学检查显示,C. paniculatus可以防止海马和前皮层的神经元损失.
结论:
- 塞拉斯特鲁斯 (Celastrus paniculatus) 种子提取物显示出显著的抗和增强认知功能的特性.
- 提取物表现出抗氧化和神经保护作用,可能通过调节多巴胺水平和氧化应激通路.
- 在与常规治疗相结合的情况下,C. paniculatus具有治疗及其相关认知缺陷的潜力.
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